Pdx1-CreERT2
Product ID:
C001537
Background:
C57BL/6JCya
Documents:
Expressing Tissues/Cells:
Islet cells
Product Type
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Genotype
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Basic Information
Model Name
Pdx1-CreERT2
Product ID
C001537
Gene Name
Background
C57BL/6JCya
Gene Alias
Ipf1; IDX-1; IPF-1; Mody4; STF-1; pdx-1
Classification
Cre Driver Lines
NCBI ID
Phenotype
Chromosome
5
Document
Note: When using this mouse strain in a publication, please cite “Pdx1-CreERT2 mice (Catalog C001537) were purchased from Cyagen.”
Strain Description
The pancreatic and duodenal homeobox 1 gene (PDX1) encodes a specific transcription factor that regulates pancreatic development and β-cell-specific gene expression. It is also the first molecular marker during pancreatic stem cell differentiation and maturation. In this model, the ‘P2A-CreERT2’ cassette is inserted upstream of the TGA stop codon in the mouse Pdx1 gene. When Pdx1-CreERT2 mice are crossed with mice containing loxP sites, tamoxifen induction can trigger sequence recombination between the loxP sites mediated by Cre recombinase in the pancreas of the offspring. It’s important to note that some leaky expression of CreERT2 recombinase may be observed without tamoxifen treatment.
Validation Data
References