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Catalog Number: I001159
Strain Name: C57BL/6JCya-Prox1em2(P2A-CreERT2)/Cya
Genetic Background: C57BL/6JCya
Examples of Expressing Tissues/Cells: lymphatic endothelial cells
Strain Description
The TAG stop codon was replaced with the "P2A-CreERT2" cassette. CreERT2 recombinase is expressed under the regulatory control of Prox1 gene elements. This model is a Tamoxifen-inducible Cre mouse, and when crossed with mice containing loxP sites, the offspring mice are expected to undergo sequence recombination between loxP sites mediated by Cre recombinase in lymphatic endothelial cells following Tamoxifen induction.
Announcement
The insertion site of the CreERT2 recombinase gene expression cassette in this strain is located on chromosome 1. Please avoid breeding with gene-edited mice targeting genes on the same chromosome as the Cre mouse when conducting mating.