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Catalog Number: I001168
Strain Name: C57BL/6JCya-Syn1em1(IRES-CreERT2)/Cya
Genetic Background: C57BL/6JCya
Examples of Expressing Tissues/Cells: nervous system (higher expression in cortex, relatively less in the striatum), genitourinary system (higher expression in male germ cells than in female germ cells)
Strain Description
The "IRES-CreERT2" cassette was inserted 22bp downstream of the TGA stop codon. CreERT2 recombinase is expressed under the regulatory control of Syn1 gene elements. This model is a Tamoxifen-inducible Cre mouse, and when crossed with mice containing loxP sites, the offspring mice are expected to undergo sequence recombination between loxP sites mediated by Cre recombinase in cells such as neurons following Tamoxifen induction.
Announcement
The insertion site of the CreERT2 recombinase gene expression cassette in this strain is located on chromosome X. Please avoid breeding with gene-edited mice targeting genes on the same chromosome as the Cre mouse when conducting mating.