Il12rb1 KO
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
Il12rb1 KO
Product ID
C001214
Gene Name
Background
C57BL/6NCya
Gene Alias
CD212; IL-12R[b]; IL-12R-beta-1
Classification
Immunodeficient Mouse Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
8
Document
Note: When using this mouse strain in a publication, please cite “Il12rb1 KO mice (Catalog C001214) were purchased from Cyagen.”
Strain Description
Il12rb1 knockout (KO) homozygous mice exhibit reduced serum levels of interferon-gamma (IFN-γ) in response to recombinant IL-12 or lipopolysaccharide (LPS) treatment. Additionally, splenocytes from these mice activated by concanavalin A (ConA) in response to IL-12 cannot proliferate or secrete IFN-γ. These homozygous mice are viable and fertile.
Application Area
Immune System-Related Research
Validation Data