Usp26 KO
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
Usp26 KO
Product ID
C001266
Gene Name
Background
C57BL/6NCya
Gene Alias
--
Classification
Metabolic Disease Models,Rare Disease Models
NCBI ID
Phenotype
Chromosome
X
Document
Note: When using this mouse strain in a publication, please cite “Usp26 KO mice (Catalog C001266) were purchased from Cyagen.”
Strain Description
Ubiquitin-Specific Protease 26 (USP26), which belongs to the ubiquitination-specific processing protease family, is a deubiquitinating enzyme with histidine (His) and cysteine (Cys) structural domains. the USP26 gene is specifically expressed in testicular tissue as well as in the blood-testis barrier, and premeiotic spermatogonia during spermatogenesis The gene is expressed in the spermatogonia before meiosis during spermatogenesis, including primitive A-, Ap- and B-type spermatogonia. The main diseases associated with USP26 are male infertility, including weak teratozoospermia, non-obstructive azoospermia (NOA), Sertoli cell-only syndrome (SCOS), and Klinefelter syndrome (KS). Homozygous Usp26 KO mice are viable.
Application Area
This strain can be used in the study of male hypo fertility associated with defective spermatogenesis including Creutzfeldt-Jakob syndrome
Validation Data