B6-hSCN9A
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
B6-hSCN9A
Product ID
I001216
Gene Name
Background
C57BL/6NCya
Gene Alias
PN1; ETHA; NENA; SFNP; FEB3B; NE-NA; GEFSP7; HSAN2D; Nav1.7
Classification
Full-Gene Humanized Models,Other Disease Models
NCBI ID
Phenotype
Chromosome
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Datasheet
Note: When using this mouse strain in a publication, please cite “B6-hSCN9A mice (Catalog I001216) were purchased from Cyagen.”
Strain Description
The B6-hSCN9A mouse is a mouse Scn9a humanized model, generated by replacing the mouse Scn9a gene (including the 5' UTR and 3' UTR) with the corresponding human SCN9A gene sequence using gene editing technology. Internal research revealed that during the generation of B6-hSCN9A mice, the murine Scn9a gene was inserted unexpectedly, and its precise genomic insertion site remains undetermined. This strain is suitable for studying the pathogenic mechanisms of neurological diseases such as erythromelalgia, Dravet syndrome, small fiber neuropathy, and congenital insensitivity to pain, as well as for screening analgesic drug candidates. In addition, based on the independently developed TurboKnockout fusion BAC recombination technology, Cyagen can also provide customized services.
Application Area
Research on erythromelalgia, Dravet syndrome, small fiber neuropathy, and congenital insensitivity to pain
Pathogenic mechanisms of other neurological diseases and analgesic drug research
Validation Data