Pde6b KO
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Model Name
Pde6b KO
Product ID
C001384
Gene Name
Background
C57BL/6JCya
Gene Alias
r; rd; rd1; Pdeb; rd-1; rd10
Classification
Ophthalmic Disease Models,Rare Disease Models
NCBI ID
Phenotype
Chromosome
5
Document
Note: When using this mouse strain in a publication, please cite “Pde6b KO mice (Catalog C001384) were purchased from Cyagen.”
Strain Description
This strain is a mouse Pde6b knockout model that uses gene editing technology to knock out the homolog of the human PDE6B gene in mice. The deletion of Pde6b gene expression in mice leads to dysfunction of the cGMP-PDE complex and rapid apoptosis of optic rod cell photoreceptors, causing severe retinal degeneration (RD), and the progression of ocular retinal disease in this model is similar to that of mice carrying the RD1 spontaneous mutations in the mouse Pde6b gene, which is a class of animal models of early-onset retinal degeneration.
Application Area
Retinitis Pigmentosa (RP) Research
Congenital Stationary Night Blindness (CSNB) Research
Other Eye Disease Research
Validation Data