B6-hCEP290
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-hCEP290
Product ID
I001217
Gene Name
Background
C57BL/6JCya
Gene Alias
CT87; MKS4; POC3; rd16; BBS14; JBTS5; LCA10; NPHP6; SLSN6; 3H11Ag
Classification
Full-Gene Humanized Models,Ophthalmic Disease Models
NCBI ID
Phenotype
Chromosome
12
Document
Note: When using this mouse strain in a publication, please cite “B6-hCEP290 mice (Catalog I001217) were purchased from Cyagen.”
Strain Description
This strain is a humanized mouse model of Cep290, in which the endogenous mouse Cep290 gene is replaced by the human CEP290 gene using gene-editing technology. It can be used to study Leber Congenital Amaurosis type 10 (LCA10).
Application Area
Research on Leber congenital amaurosis type 10 (LCA10)
Research on Joubert syndrome and nephronophthisis
Validation Data