Humanized Immune System Mouse Models

"Humanized mice" refer to mouse models that carry functional human genes, cells, tissues, or organs/immune systems and can be used for biomedical research and the development of clinical treatment strategies. One notable category within this field is the creation of mice with humanized immune systems, often referred to as humanized immune system mice. These models are developed by transplanting human hematopoietic stem cells, immune cells, or tissues into immunodeficient mice, resulting in a unique mouse model with human immune functionality.

Categories of Humanized Immune System Mice Models

Humanized immune system mice are classified into three distinct categories based on the methodology employed for immune system reconstruction:

  1. Humanized peripheral blood mononuclear cells (huPBMCs, a.k.a. hu-PBMCs, PBMC humanized) or humanized-peripheral blood lymphocytes (Hu-PBLs) mice
  2. Humanized hematopoietic stem cells (huHSCs, a.k.a. Hu-HSCs, HSC Humanized) mice
  3. Humanized bone marrow, liver, thymus (huBLT a.k.a. Hu-BLT, HSC Humanized) mice

Common Humanized Immune System Mouse Models

Prominent examples of humanized immune system mouse models include humanized PBMC (huPBMC) mice and humanized HSC (huHSC) mice. Cyagen’s NKG immunodeficient mice offer versatility, accommodating transplantation with either PBMCs or HSCs to construct highly effective human immune system mouse models.

This innovative approach facilitates a more accurate simulation of the human immune response, providing exceptional models for preclinical research across various areas, including tumor immunology, autoimmune diseases, and specific infectious diseases.

Mouse Models Overview:

Mouse Name Transplant Graft Source Project Time Immune Reconstitution Status Research Applications Order
huPBMC-NKG Human peripheral blood mononuclear cells (PBMC) Achieving a humanization ratio of over 40% within 3 weeks. Predominantly T cells, accounting for over 90%. Tumor immunology research; anti-GvHD drug research; infectious disease research; gene therapy; drug target research without cross-reactivity; immunogenicity assays. Inquire Now
huHSC-NKG Human hematopoietic stem cells (HSC) from umbilical cord blood. Reaching a humanization ratio of over 50% within 6 weeks. Reconstruction of various immune cells. Tumor research; immunology research; autoimmune disease research; drug metabolism and toxicity research. Inquire Now
huHSC-NKG-hIL15 Human hematopoietic stem cells (HSC) from umbilical cord blood. Rapid reconstruction achieved in the 3rd week post-transplantation; Reconstruction of various immune cells, especially effective reconstruction of human-derived NK cells; Studies on NK cell development mechanisms, development of NK cell-related tumor immunotherapy, studies on antibody-dependent NK cell-mediated cytotoxicity (ADCC); research on human immune and hematopoietic systems. Inquire Now
In summary, these humanized immune system mouse models, enhanced by cutting-edge methodologies, offer valuable insights into human immune responses and pave the way for advanced research in diverse medical fields. Explore the possibilities of these models to elevate your preclinical studies and contribute to advancements in biomedical science. Contact us today for a free consultation for your preclinical research.