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huHSC-NKG Mouse
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huHSC-NKG Mouse
Product Name
huHSC-NKG Mouse
Product ID
C001328
Strain Name
huHSC-NOD.Cg-PrkdcscidIl2rgem1cya/Cya
Backgroud
NKG
When using this mouse strain in a publication, please cite “huHSC-NKG Mouse (Catalog C001328) were purchased from Cyagen.”
Immunodeficient Mice
Humanized Immune System Models
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Immunodeficient Mice
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Basic Information
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Basic Information
Gene Name
Il2rg
Gene Alias
gc, p64, [g]c, CD132, gamma(c)
NCBI ID
16186
Chromosome
Chr X
MGI ID
--
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Datasheet
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Strain Description
NKG mice (catalog number: C001316) are a kind of severe immunodeficient mice generated by Cyagen through deleting the Il2rg gene from NOD-Scid mice. NKG mice exhibit deficiency of mature T cells, B cells, and functional NK cells, reduced complement activity, and weak phagocytosis of human-derived cells by macrophages, which are well suited for the transplantation of human hematopoietic stem cells (HSC), peripheral blood mononuclear cells (PBMC), adult stem cells and tissues, and patient-derived xenograft (PDX).
huHSC-NKG mice are immune system humanized mouse models constructed by transplanting human hematopoietic stem cells (HSC) into NKG mice after sub-lethal dose irradiation. This model has a long lifespan and can successfully reconstitute a variety of immune cells. Furthermore, huHSC-NKG mice typically do not develop graft-versus-host disease (GvHD) and the reconstitution period can be lengthy.
Strain Strategy
Female NKG mice aged 4-5 weeks were selected to inject CD34+ hematopoietic stem cells (HSCs) through the tail vein after irradiation, and the reconstitution period was 12-16 weeks.
Application Area
Research on the immune system and tumor immunity;
Research on hematopoietic development and blood diseases;
Research on infectious diseases such as HIV and AIDS;
Research on tumor transplantation and anti-tumor drug efficacy.
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