HBB-bs & HBB-bt DKO
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Basic Information
Model Name
HBB-bs & HBB-bt DKO
Product ID
C001508
Background
C57BL/6JCya
Gene Alias
Hbbt1; Hbbt2; Beta-s; Beta-t
Classification
Rare Disease Models
Phenotype
Chromosome
7
Document
Note: When using this mouse strain in a publication, please cite “HBB-bs & HBB-bt DKO mice (Catalog C001508) were purchased from Cyagen.”
Strain Description
C57BL/6Cya mice have two similar adult β-globin protein-encoding genes, Hbb-bs and Hbb-bt. These two genes are located at adjacent positions on mouse chromosome 7 and contain three exons. Hbb-bs & Hbb-bt DKO mice are a β-thalassemia disease model constructed by simultaneously knocking out the Hbb-bs gene and Hbb-bt gene in C57BL/6JCya mice using gene editing technology. This model is homozygous lethal, and heterozygous mice show typical features of severe thalassemia, such as abnormal hemoglobin content, red blood cell count, hematocrit, mean corpuscular hemoglobin concentration, red cell distribution width, platelet count, spleen size, and red cell morphology, and have reproductive ability.
Application Area
Studying the mechanisms of β-thalassemia and screening potential therapeutic agents
Validation Data