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KO cell
What are Knockout Cell Lines Used For?
Jun 17, 2021
As an easy-to-use and powerful gene-editing tool, CRISPR-Pro has been widely used in applications ranging from basic research to the treatment of genetic diseases. The development of this technology has made the generation of knockout (KO) cell line models more accessible. Why use knockout cell lines? In this article, we review the various applications of the knockout cell lines, hoping to bring some inspiration for your research. Read More >
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Expert Webinar: Introduction to Genetically Engineered Rodent Models
Jun 15, 2021
View our Expert Webinar to learn about cutting-edge genome editing technologies and application limitations of animal models - such as genetically modified mice and rats. Read More >
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Exhibiting at International Society for Stem Cell Research (ISSCR) 2021
Jun 11, 2021
Cyagen Biosciences is looking forward to virtually exhibiting at the International Society for Stem Cell Research (ISSCR) Annual Meeting Read More >
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Leveraging Humanized Mice for Human Antibody Discovery
Jun 08, 2021
With the rapid development of human antibody production, using gene editing technology to construct humanized mice with human antibodies has become an important subject in antibody drug discovery Read More >
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Human Antibody Discovery Using In-vivo Mouse Models
Jun 08, 2021
The continuous development and improvement of gene editing technology has driven the successful establishment of such a platform for mouse models expressing human antibody genes Read More >
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Important Considerations in the Humanization of Antibodies
Jun 08, 2021
The clinical application of mouse-derived antibodies has revealed some limitations, such as causing human anti-mouse antibody (HAMA) reaction, an allergic reaction that might accelerate clearance of mouse antibodies and cause anaphylaxis. Read More >
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How Are Therapeutic Antibodies Developed?
Jun 08, 2021
The therapeutic antibody has become a leading treatment option for cancers and other related diseases. In the past 25 years, antibody therapy has become an important treatment method for various diseases, such as cancer. Notably, from 2018 to 2019, there were about 18 new therapeutic antibody drugs approved for clinical use. Read More >
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In Vivo Tumor Models - Cell Line-derived Tumor Xenograft (CDX) Models in Oncology Research
Jun 06, 2021
In vivo tumor models, such as cell line-derived tumor xenograft (CDX) models, play an important role in basic research of tumorigenesis and metastasis, as well as drug development and treatment. Read More >
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What Are Immunodeficient Mice
Jun 04, 2021
Immunodeficient mice refer to the mice with defects in one or more immune components (such as T, B, NK cells) in the immune system. This type of mouse is widely used in the research of oncology (tumor growth, metastasis, anti-tumor drug screening), immunology (mechanisms of immune cell development and proliferation, pathology of immune diseases), infectious diseases (pathogenic mechanisms of viral/bacterial infectious diseases), and stem cell biology (human stem cell transplantation), and more. Read More >
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Introduction to Tumor Models for Research
Jun 04, 2021
The establishment of tumor animal models provide a powerful tool for studying the mechanism of tumorigenesis and metastasis, even validating the efficacy of anti-tumor drugs. Rodent models have many advantages in tumor research, such as fast breeding, low cost, and versatile genetic modification. These traits make them an indispensable tool for preclinical therapeutics screening. Read More >