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Cyagen Knockout Catalog Model Resource - Improve Your Research Efficiency
May 06, 2021
With continuous advancement, our se Read More >
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Research Trend
Cyagen Conditional Knockout Mouse Model Publication Alert
Apr 29, 2021
The following publications demonstrate the use of conditional knockout mouse models across a range of human disease research fields, including immunology, cardiology, metabolomics, oncology and more. Read More >
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Research Trend
Alzheimer's Disease Research Resources List
Apr 21, 2021
Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder, which affects 20 to 30 million individuals worldwide. Currently, no effective therapies to treat or cure this disease have been developed. Read More >
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Research Trend
Knockout Mice - An Efficient Tool for Gene Function Research
Apr 02, 2021
Knockout mice have been essential for gaining proper understanding of gene function, studying human disease mechanisms, and accelerating drug development - playing an important role in biomedical advancements across a variety of research areas. With the development of gene editing technology, knockout (KO) mice become increasingly accessible for researchers worldwide. In this article, we review the basic information on knockout mice research, application examples, and the development process for custom KO mouse models. Read More >
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Research Trend
Rare Disease Research and Gene Therapy Resources List
Mar 29, 2021
As a leading provider of custom mouse and rat models, Cyagen aims to support the advancement of rare disease and related gene therapy research with our expertise. We are committed to enabling development of therapeutics for rare diseases by developing accessible animal models to study disease mechanisms, target validation, drug screening and more. Read More >
Newsletter
Weekly Gene
Pathogenic Genes of Rare Disease - SMN1 in Spinal Muscular Atrophy Research
Mar 05, 2021
cord, which affects the central nervous system, peripheral nervous system, and voluntary muscle movement. The primary pathogenic gene of spinal muscular atrophy is the survival of motor neuron 1 (SMN1) gene, mutations of which cause a deficiency of SMN motor neuron protein – ultimately resulting in Chromosome 5 SMA, the most common form of SMA. Read More >
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Breaking News
Rare Disease Day 2021 – Achieving Equity
Feb 26, 2021
With over 300 million people worldwide living with a rare disease, Rare Disease Day aims to raise awareness of what it means to be rare. On the last day of February each year, the Rare Disease community comes together to work toward more equitable access to diagnosis, treatment, care, and social opportunity for people with a rare disease. Read More >
Newsletter
Weekly Gene
【Gene of the Week】Metabolism & Cardiovascular Diseases - SIRT3
Feb 26, 2021
The SIRT3 gene plays an important role in the pathogenesis of metabolic, cardiovascular, and neurodegenerative diseases. In this article, we review the functionality of SIRT3 and explore its role in metabolism & cardiovascular disease studies - bringing together insights to SIRT3 gene research developments to provide inspiration for your scientific innovation. Read More >
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Video
The PiggyBAC Transposon - Generating Transgenic Mice with Consistent Expression
Feb 23, 2021
In most experiments, scientists will try to minimize the number of independent variables so as not to confuse the results of an experiment. Due to the varying level of gene expression achieved by traditional pronuclear injection (PNI), using the offspring from a transgenic mouse created via PNI may not be the best option. Read More >
Research Trend
Newsletter
COVID-19
Beyond Alzheimer’s Disease – Implications of APOE in Viral Pathology
Feb 09, 2021
The APOE gene - which encodes Apolipoprotein E – has been extensively studied due to its biological relevance to a range of neurological and cardiovascular diseases, including Alzheimer’s Disease (AD). In addition to the roles APOE plays in developmental diseases such as AD, additional studies have shown APOE to be implicated in the host response to a range of infectious pathogens, including herpes simplex virus type I (HSV1) and hepatitis C virus (HCV). Read More >