Animal modeling has played a prominent role in traditional scientific research for hundreds of years. More recently, inbred strains have been developed to support genetically modified models – sometimes called the “living reagents” or “living instruments” of biomedical and health research. Additionally, gene-edited animal models are widely adopted by drug R&D companies, scientific research institutions, and laboratories worldwide in analyzing the function of disease-related genes, studying signaling pathways, identifying drug targets, screening new drugs, and more.


View our Expert Webinar to learn about cutting-edge genome editing technologies and application limitations of animal models - such as genetically modified mice and rats.


Expert Webinar: Topics in Genetically Engineered Murine Models

Cyagen’s exclusive webinar, titled “Platform for Rapid Generation of Genetically Engineered Mouse/Rat Models,” introduces the techniques used to produce genetically engineered models. This webinar is presented by Cyagen’s Chief Scientific Officer, Dr. Marvin Ouyang, who has over 20 years of dedicated experience developing custom rodent models.

Presented by:

Dr. Marvin Ouyang
Executive Vice President and Chief Scientific Officer

Dr. Marvin Ouyang has been dedicated to the development of genetically engineered rodent models for the past 20 years, developing hundreds of transgenic and KO/KI mouse/rat models for biomedical research and drug development. Previously, he served as the senior scientist of Oklahoma Medical Research Foundation (OMRF), a scientist for U.S.-based Thios Pharmaceuticals, and worked for Taconic Biosciences as the leader of the Molecular Biology Department. So far, he has published many papers in high-impact academic journals such as PNAS and JBC. Technical services developed by Dr. Ouyang have been directly cited hundreds of times by top international journals, including Nature.


Main Topics:

● Strategies and methods of different gene-editing technologies
● Generation of transgenic mice by pronuclear injection (PNI)
● Homologous recombination in embryonic stem (ES) cells
● Comparison of Gene Targeting (GT) and pronuclear injection (PNI)
● Nuclease-induced genome editing – Applications of CRISPR
● Pros and cons of CRISPR-Pro-mediated Genome Editing
● TurboKnockout® - Accelerating ES Cell Gene Targeting


Video: Rapid Generation of Genetically Engineered Rodent Models

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About Cyagen - Comprehensive Research Model Support

In under 15 years, Cyagen has become a leading provider of custom mouse and rat models – delivering over 78,400 models to researchers worldwide. Our products and services have been cited in over 4,700 papers cross highly reputed publications and journals including Cell, Nature, Science and more – all of which are available as a searchable list:

>> Browse All Citations


As a global leader in animal model services, Cyagen provides comprehensive gene knockout (KO), gene knockin (KI), conditional knockout (cKO), humanization, and other model customization services to meet your research needs. Cyagen prides itself on its premium customer service: including price-matching, client access to complimentary technical consultations, full confidentiality, and a 100% money-back service guarantee.


Why Choose Cyagen?

1. Complete research solutions – from custom rodent model generation to therapeutic viral packaging and injection.

2. Both in vivo (animal) and in vitro (cell) experimental models available

3. Expert scientific team provides in-depth technical support in formulating research model strategies.


Contact Our Model Generation Experts

From strategy design through to delivery of research-ready custom models, Cyagen offers complete outsourcing for all your animal model needs. We can create any custom mouse or rat model with guaranteed genotype validation, even offering phenotypic characterization and other downstream services required to establish a research model.

Contact us with your project details to request your complimentary model generation project consultation, strategy, and quote.