Trem2 KO
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Strain Description
This strain is a mouse model with the Trem2 gene knocked out, which can be used to study the biological consequences of TREM2 functional loss. It can also be crossed with transgenic mice related to APP and tau proteins to study the impact of TREM2 functional loss in the context of amyloid degeneration and tau pathology. Homozygous Trem2 KO mice are viable and fertile.
Application Area
Research on the pathogenesis of neurodegenerative diseases
Studies on the impact of immune responses and inflammation on the nervous system
Screening and evaluation of potential drugs targeting Trem2 or its pathway
Research on the genetic mechanisms of diseases such as Nasu-Hakola disease
Studies on amyloid degeneration and tau protein pathology
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