Preclinical Neuropathic Pain CRO Services
Why Preclinical Neuropathic Pain Models Matter
Neuropathic pain arises from injury or dysfunction within the somatosensory system and is frequently associated with persistent sensory abnormalities, including mechanical allodynia, cold hypersensitivity, thermal hyperalgesia, and altered motor behavior. To address this clinical complexity, Cyagen offers a validated in vivo neuropathic pain model portfolio, including the mouse chronic constriction injury (CCI) model, rat spinal nerve ligation (SNL) model, and cisplatin-induced pain mouse model. These models support studies across peripheral nerve injury, spinal nerve injury, and chemotherapy-induced peripheral neuropathy.
Moving beyond single-endpoint reflex assays, Cyagen’s surgery-based and pharmacologically induced models enable multidimensional behavioral profiling and pharmacodynamic evaluation. By combining baseline model validation, positive-control benchmarking, and comprehensive sensory and motor readouts, Cyagen helps pharmaceutical developers assess compound mechanism of action (MOA), de-risk therapeutic pipelines, and generate reproducible data to support confident Go/No-Go decisions and IND-enabling research.
Disease-Specific Animal Models for Neuropathic Pain
Cyagen provides both surgery-based and pharmacologically induced neuropathic pain models to support behavioral validation, analgesic efficacy testing, and functional characterization in mice and rats.
Disease-Relevant Neuropathic Pain Models
| Model | Species | Key Mechanism | Pathology & Clinical Relevance | Action |
|---|---|---|---|---|
| Mouse Chronic Constriction Injury (CCI) Model | mice | Surgical exposure and four ligations of the main trunk of the sciatic nerve. | Mimics chronic constriction injury (CCI) and peripheral neuropathic pain. Models exhibit robust mechanical allodynia and cold hyperalgesia. | |
| Spinal nerve ligation (SNL) Model | SD rats | L5 spinal nerve exposure and ligation following removal of the L5 transverse process | Clinically relevant model for peripheral neuropathy. Induces stable, long-lasting mechanical allodynia and significant weight-bearing asymmetry (shortened stride length). | |
| Cisplatin-Induced Pain Mouse Model | mice | Repeated intraperitoneal cisplatin administration twice weekly for three weeks, followed by longitudinal von Frey and cold plate assessment. | Models chemotherapy-induced peripheral neuropathy. Mice exhibit stable mechanical hyperalgesia and cold hyperalgesia, supporting pain mechanism and analgesic pharmacodynamic studies. |
Relevant Mouse Models
| Catalog Number | Name | Base Strain | Research Application | Action |
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In Vivo Pharmacology Services
Precision Model Induction & Study Design
- Stereotactic Administration
- Intrathecal Administration
- Intracerebroventricular Administration
- Intracerebral Administration
- Intraperitoneal Administration
- Intravenous Administration
- Subcutaneous Administration
- Intramuscular Administration
- Histology & Imaging: IHC-P, IHC-Fr, Fluorescence Imaging
- Molecular & Protein Analysis: Western Blot, ELISA, qPCR
- Sample Collection & Reporting: Tissue Collection, Figure-Ready Data Reporting
Comprehensive Behavioral Analytics
| Assessment Category | Specific Services |
|---|---|
| Cold Sensitivity Assessment | EtOH stimulation |
| Cold plate test | |
| Mechanical Sensitivity Assessment | Electronic Von Frey |
| Thermal Sensitivity Assessment | Hargreaves test |
| Tail flick test | |
| Hot plate test | |
| Motor and Functional Assessment | Gait test |
| Open field | |
| Rotarod test | |
| Spontaneous Pain-Related Behavior | Face-grooming behavior test |
Case Studies
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CCI Model Shows Mechanical and Cold Hypersensitivity After Surgery
SNL Model Shows Gait Impairment and Mechanical Allodynia
Cisplatin-Induced Model Shows Mechanical and Cold Hyperalgesia
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