This strain is a mouse Pde6b knockout model that uses gene editing technology to knock out the homolog of the human PDE6B gene in mice. The deletion of Pde6b gene expression in mice leads to dysfunction of the cGMP-PDE complex and rapid apoptosis of optic rod cell photoreceptors, causing severe retinal degeneration (RD), and the progression of ocular retinal disease in this model is similar to that of mice carrying the RD1 spontaneous mutations in the mouse Pde6b gene, which is a class of animal models of early-onset retinal degeneration.