Rpe65 KO
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Strain Description
This product is a mouse Rpe65 knockout model that uses gene editing technology to knock out the homolog of the human RPE65 gene in mice. The deletion of Rpe65 gene expression in mice resulted in disruption of RPE cell function, apoptosis of photoreceptor cells, disorganization of the outer segmental discs of optic rods, and quenching of optic rod waveforms, causing severe retinal degeneration.
Application Area
Retinal Degeneration (RD) Research
Leber Congenital Amaurosis 2 (LCA2) Research
Other Retinal Disease Research
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