B6-htau
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
B6-htau
Product ID
C001410
Gene Name
Background
C57BL/6JCya
Gene Alias
TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; tau-40; FTDP-17; PPP1R103; Tau-PHF6
Classification
Full-Gene Humanized Models,Neurological Disease Models
NCBI ID
Phenotype
Chromosome
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Note: When using this mouse strain in a publication, please cite “B6-htau mice (Catalog C001410) were purchased from Cyagen.”
Strain Description
This strain is a humanized mouse model in which the endogenous mouse Mapt gene has been replaced with its human counterpart, including the 3'UTR region. This model can be utilized to study various neurodegenerative diseases, such as FTD and AD. This model is commonly named htau. In addition, based on the independently developed TurboKnockout fusion BAC recombination technology, Cyagen can also generate hot mutation models based on this strain and provide customized services for specific mutations to meet the experimental needs in pharmacology and other fields.
Application Area
Research on Frontotemporal dementia (FTD)
Research on Alzheimer's disease (AD)
Research on other neurodegenerative diseases
Validation Data