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B6-hCTLA4
Product ID:
C001413
Background:
C57BL/6NCya
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Strain Description
This strain was generated by gene editing to replace the extracellular domain of Ctla4 in mice with the humanized version, resulting in a model that expresses the extracellular domain of human CTLA4 and the intracellular domain of mouse CTLA4. This model can be used for the research of the development and screening of CTLA4-related inhibitors or antibody drugs, the evaluation of pharmacodynamics and safety, the evaluation of tumor immunotherapy, and the mechanisms of the immune system.
Application Area
Area
Development and screening of CTLA4-targeted inhibitors/antibody drugs
Area
Evaluation of the efficacy and safety of CTLA4-targeted inhibitors/antibody drugs
Area
Evaluation of tumor immunotherapy and research on the mechanisms of the immune system
Area
Research on autoimmune diseases
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