Nr2e3 KO
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Model Name
Nr2e3 KO
Product ID
C001425
Gene Name
Background
C57BL/6JCya
Gene Alias
PNR; RNR; rd7; A930035N01Rik
Classification
Ophthalmic Disease Models,Rare Disease Models
NCBI ID
Phenotype
Chromosome
9
Document
Note: When using this mouse strain in a publication, please cite “Nr2e3 KO mice (Catalog C001425) were purchased from Cyagen.”
Strain Description
This strain is a mouse Nr2e3 knockout model that uses gene editing technology to knock out the homolog of the human NR2E3 gene in mice. The absence of the Nr2e3 gene in mice can lead to the appearance of pathological retinal spots, late-onset retinal degeneration, reduced ERG amplitude in rod cells, and folding and vortices in the photoreceptor layer. The Nr2e3 KO mice can be used as a model for enhanced S-cone syndrome (ESCS) research.
Application Area
Enhanced S-Cone Syndrome (ESCS) Research
Retinitis Pigmentosa (RP) Research
Other Retinal Diseases Research
Validation Data