NKG-hIL15
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Strain Description
The NKG-hIL15 mice are constructed by knocking in the human IL15 gene from the NKG mice. Compared to NKG mice, NKG-hIL15 mice significantly enhance the reconstitution proportion of human NK cells after HSC or PBMC transplantation. These mice can be utilized for the development of immunotherapies targeting NK cells and drug evaluation.
Application Area
Construction of the immune system humanized mouse models
NK cell development mechanism studies, NK cell-related tumor immunotherapy development, and antibody-dependent NK cell-mediated toxicity (ADCC) studies
Research on the human immune system, haematopoietic system
Human-derived cell line xenograft (CDX) and patient-derived xenograft (PDX)
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