NKG-hIL15
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
NKG-hIL15
Product ID
C001513
Background
NKG
Gene Alias
gc; p64; [g]c; CD132; gamma(c); IL-15
Classification
Immunodeficient Mouse Models
Phenotype
Chromosome
X
Document
Note: When using this mouse strain in a publication, please cite “NKG-hIL15 mice (Catalog C001513) were purchased from Cyagen.”
Strain Description
The NKG-hIL15 mice are constructed by knocking in the human IL15 gene from the NKG mice. Compared to NKG mice, NKG-hIL15 mice significantly enhance the reconstitution proportion of human NK cells after HSC or PBMC transplantation. These mice can be utilized for the development of immunotherapies targeting NK cells and drug evaluation.
Application Area
Construction of the immune system humanized mouse models
NK cell development mechanism studies, NK cell-related tumor immunotherapy development, and antibody-dependent NK cell-mediated toxicity (ADCC) studies
Research on the human immune system, haematopoietic system
Human-derived cell line xenograft (CDX) and patient-derived xenograft (PDX)
Validation Data