Mb1-iCre
Product ID:
C001552
Background:
C57BL/6JCya
Documents:
Expressing Tissues/Cells:
Lymphoid B Cells (Higher activity in the early developmental stages)
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Model Name
Mb1-iCre
Product ID
C001552
Gene Name
Background
C57BL/6JCya
Gene Alias
Iga; Ly54; mb-1; Ly-54; Igalpha; Ig-alpha
Classification
Cre Driver Lines
NCBI ID
Phenotype
Chromosome
7
Document
Note: When using this mouse strain in a publication, please cite “Mb1-iCre mice (Catalog C001552) were purchased from Cyagen.”
Strain Description
The MB1 gene, CD79a, is critical in the immune system. It encodes the Ig-α protein, a key component of the B cell antigen receptor complex. Mb1-iCre mice were generated by integrating a codon-optimized Cre recombinase gene (iCre) expression cassette, which has higher recombination activity, into the endogenous Cd79a gene in the mouse, driving its specific expression. This strategy disrupts the expression of the mouse endogenous Cd79a gene. When bred with mice containing the loxP site-flanked sequence, Cre recombinase-mediated deletionof the flanked sequence is estimated to occur in the lymphoid B cells of the offspring mice, with a predicted high level of Cre recombinase activity in the early development of B cells.
Validation Data