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TG-hAPOC3
Product ID:
C001588
Background:
C57BL/6NCya
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Strain Description
The TG-hAPOC3 mouse is a humanized model generated by integrating the human APOC3 gene sequence, encompassing the upstream and downstream untranslated regions (UTRs), into the mouse genome, enabling the expression of human ApoC-III protein in vivo. This model is valuable for developing therapeutics targeting human APOC3, such as small interfering RNA (siRNA) and antisense oligonucleotides (ASOs), for the treatment of hypertriglyceridemia.
Application Area
Area
Development, screening, and preclinical efficacy evaluation of therapeutics targeting human APOC3
Area
Investigation of the pathogenic mechanisms and therapeutic strategies for hypertriglyceridemia (HTG)
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