B6-hBAFF (hTNFSF13B)
Product Type
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Genotype
Sex
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Basic Information
Model Name
B6-hBAFF (hTNFSF13B)
Product ID
C001621
Gene Name
Background
C57BL/6NCya
Gene Alias
DTL; BAFF; BLYS; CD257; TALL1; THANK; ZTNF4; TALL-1; TNLG7A; TNFSF20
Classification
Tumor Target Humanized Models,Immune Target Humanized Models,Cytokine Humanized Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
13
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Note: When using this mouse strain in a publication, please cite “B6-hBAFF (hTNFSF13B) mice (Catalog C001621) were purchased from Cyagen.”
Strain Description
The B6-hBAFF (TNFSF13B) mouse is a humanized model generated using gene editing technology, in which the protein-coding sequence (CDS) encoding the extracellular domain of the human TNFSF13B protein is integrated into a specific site within the mouse Tnfsf13b gene, while retaining the endogenous gene sequence encoding the mouse cytoplasmic and transmembrane domains (aa.1-68). Homozygous B6-hBAFF (TNFSF13B) mice are viable and fertile. This model can be used for studying the pathological mechanisms and therapeutic approaches of autoimmune diseases and specific B cell malignancies and for the development of BAFF-targeted drugs.
Application Area
BAFF-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of autoimmune diseases and specific B cell malignancies
Validation Data