B6-hIL4
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-hIL4
Product ID
C001628
Gene Name
Background
C57BL/6NCya
Gene Alias
BSF1; IL-4; BCGF1; BSF-1; BCGF-1
Classification
Immune Target Humanized Models,Cytokine Humanized Models,Full-Gene Humanized Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
5
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Note: When using this mouse strain in a publication, please cite “B6-hIL4 mice (Catalog C001628) were purchased from Cyagen.”
Strain Description
B6-hIL4 mice are humanized models generated using gene editing technology by replacing the sequences from the ATG start codon to the TAG stop codon of the endogenous mouse Il4 gene with the sequences from the ATG start codon to the TGA stop codon of the human IL4 gene. Homozygous B6-hIL4 mice are viable and fertile. This model is an invaluable tool for studying allergic diseases (e.g., asthma and atopic dermatitis), Th2 immune responses, parasitic infections, tumor immunology, and chronic inflammation. Furthermore, it serves as a robust preclinical platform for evaluating the efficacy and mechanisms of therapeutic agents targeting the IL-4.
Application Area
Investigation of immune regulation and Th2 responses, allergic diseases, parasitic infections, and tumor immunology
Preclinical development, screening, and efficacy evaluation of IL4-targeted therapeutic agents
Studies on inflammation and autoimmune diseases
Validation Data