B6-hMSTN (hGDF8)
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Basic Information
Model Name
B6-hMSTN (hGDF8)
Product ID
C001636
Gene Name
Background
C57BL/6NCya
Gene Alias
GDF8; MSLHP
Classification
Metabolic Target Humanized Models,Full-Gene Humanized Models,Metabolic Disease Models
NCBI ID
Phenotype
Chromosome
2
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Note: When using this mouse strain in a publication, please cite “B6-hMSTN (hGDF8) mice (Catalog C001636) were purchased from Cyagen.”
Strain Description
The B6-hMSTN (hGDF8) mouse is a humanized model constructed using gene editing technology, where the mouse Mstn genomic DNA (aa.25~376) was replaced with the human MSTN genomic DNA (aa.24~375). The murine signal peptide (aa.1~24) was preserved. This model can be used for studying the pathological mechanisms and therapeutic approaches of muscular dystrophy, sarcopenia and metabolic syndrome, and for the development of MSTN-targeted drugs.
Application Area
MSTN-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of muscular dystrophy, sarcopenia and metabolic syndrome
Validation Data