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B6-hMSTN (hGDF8)
Product ID:
C001636
Background:
C57BL/6NCya
Documents:
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Strain Description
The B6-hMSTN (hGDF8) mouse is a humanized model constructed using gene editing technology, where the mouse Mstn genomic DNA (aa.25~376) was replaced with the human MSTN genomic DNA (aa.24~375). The murine signal peptide (aa.1~24) was preserved. This model can be used for studying the pathological mechanisms and therapeutic approaches of muscular dystrophy, sarcopenia and metabolic syndrome, and for the development of MSTN-targeted drugs.
Application Area
Area
MSTN-targeted drug screening, development, and evaluation
Area
Research on the pathological mechanisms and therapeutic approaches of muscular dystrophy, sarcopenia and metabolic syndrome
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