B6-huTRP53
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Model Name
B6-huTRP53
Product ID
C001640
Gene Name
Background
C57BL/6JCya
Gene Alias
P53; BCC7; LFS1; BMFS5; TRP53
Classification
Tumor Target Humanized Models,Full-Gene Humanized Models
NCBI ID
Phenotype
Chromosome
--
Document
Note: When using this mouse strain in a publication, please cite “B6-huTRP53 mice (Catalog C001640) were purchased from Cyagen.”
Strain Description
B6-huTRP53 mouse is a humanized model constructed via gene editing technology, in which the region from ATG start codon to ~500 bp downstream of 3'UTR of mouse Trp53 is replaced with the region from ATG start codon to ~500 bp downstream of 3'UTR of human TP53. Initial research has shown that breeding the homozygous line results in a very small number of pups. While heterozygous females can breed normally, their maternal instincts are poor, with instances of cannibalism and occasional deaths of pups due to a failure to thrive. B6-huTRP53 mouse can be used for mechanistic research on a wide range of cancers, including hereditary cancers like Li-Fraumeni syndrome and preclinical studies of TP53-targeted drugs.
Application Area
Screening, development, and preclinical evaluation of TP53-targeted drugs
Mechanistic research on a wide range of cancers, including hereditary cancers like Li-Fraumeni syndrome, and evaluation of therapeutic drugs
Validation Data