The rhodopsin encoded by the Rhodopsin gene (RHO) is closely related to visual light transduction and GPCR downstream signaling, and rhodopsin is crucial for the transmission of light signals in the process of visual formation. Retinitis pigmentosa (RP) is an inherited retinal disease with a global incidence of about 1:5000-1:3000. RP has a large clinical and genetic heterogeneity, and mutations in the RHO gene account for about 25% of dominant RP. This strain is a mouse Rho gene humanized model. The sequences from ~4.5 kb upstream of exon 1 to ~0.5 kb downstream of exon 5 of mouse Rho will be replaced with the sequences from ~7 kb upstream of exon 1 to ~0.5 kb downstream of exon 5 of human RHO. This model can be used to study visual signaling and retinitis pigmentosa (RP).