B6-hRHO (Promoter)
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Basic Information
Model Name
B6-hRHO (Promoter)
Product ID
C001646
Gene Name
Background
C57BL/6JCya
Gene Alias
RP4; OPN2; CSNBAD1
Classification
Full-Gene Humanized Models,Ophthalmic Disease Models,Rare Disease Models
NCBI ID
Phenotype
Chromosome
3
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Note: When using this mouse strain in a publication, please cite “B6-hRHO (Promoter) mice (Catalog C001646) were purchased from Cyagen.”
Strain Description
The rhodopsin encoded by the Rhodopsin gene (RHO) is closely related to visual light transduction and GPCR downstream signaling, and rhodopsin is crucial for the transmission of light signals in the process of visual formation. Retinitis pigmentosa (RP) is an inherited retinal disease with a global incidence of about 1:5000-1:3000. RP has a large clinical and genetic heterogeneity, and mutations in the RHO gene account for about 25% of dominant RP. This strain is a mouse Rho gene humanized model. The sequences from ~4.5 kb upstream of exon 1 to ~0.5 kb downstream of exon 5 of mouse Rho will be replaced with the sequences from ~7 kb upstream of exon 1 to ~0.5 kb downstream of exon 5 of human RHO. This model can be used to study visual signaling and retinitis pigmentosa (RP).
Application Area
Research on retinitis pigmentosa (RP)
Research on congenital stationary night blindness (CSNB)
Research on other retinal diseases
Validation Data