B6-hCRBN
Product Type
Age
Genotype
Sex
Quantity
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Contact for Pricing
Basic Information
Model Name
B6-hCRBN
Product ID
C001683
Gene Name
Background
C57BL/6JCya
Gene Alias
MRT2; MRT2A
Classification
Tumor Target Humanized Models,Immune Target Humanized Models
NCBI ID
Phenotype
Chromosome
3
Document
Note: When using this mouse strain in a publication, please cite “B6-hCRBN mice (Catalog C001683) were purchased from Cyagen.”
Strain Description
B6-hCRBN mice are humanized models generated by gene editing technology, in which the exon 2 to partial intron 2 of the mouse Crbn gene was replaced in situ with the Exon 2~11 of the coding sequence (CDS) of human CRBN gene. This model can be used to study the pathological mechanisms and therapeutic methods of autosomal recessive nonsyndromic intellectual disability and multiple myeloma and other hematological cancers, as well as the screening, development, and preclinical efficacy and safety evaluation of CRBN-based targeted protein degradation (TBD) therapies.
Application Area
Screening, development, and preclinical efficacy evaluation of CRBN-based targeted protein degradation (TBD) therapies
Study of pathological mechanisms and therapeutic methods for autosomal recessive nonsyndromic intellectual disability
Study of pathological mechanisms and therapeutic methods for multiple myeloma and other hematological cancers
Validation Data