Rho KO
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
Rho KO
Product ID
C001700
Gene Name
Background
C57BL/6JCya
Gene Alias
Ops; RP4; Opn2; Noerg1
Classification
Ophthalmic Disease Models,Rare Disease Models
NCBI ID
Phenotype
Chromosome
6
Document
Note: When using this mouse strain in a publication, please cite “Rho KO mice (Catalog C001700) were purchased from Cyagen.”
Strain Description
The Rho KO mouse is a gene knockout model created using gene-editing techniques to knock out the coding sequence of the Rho gene (the homolog of the human RHO gene) in mice. The validation data shows that this model exhibits significant thinning of the outer nuclear layer (ONL) of the retina and abnormalities in electroretinography (ERG), effectively mimicking human disease phenotypes. Therefore, it can be used to study the pathogenic mechanisms of retinitis pigmentosa and congenital stationary night blindness, as well as for the research and development of related therapeutic interventions.
Application Area
Research on retinitis pigmentosa (RP)
Research on congenital stationary night blindness (CSNB)
Research on other retinal diseases
Validation Data