NKG-MHC dKO (H2-K1/H2-Ab1/H2-D1)
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Basic Information
Model Name
NKG-MHC dKO (H2-K1/H2-Ab1/H2-D1)
Product ID
C001705
Background
NKG
Gene Alias
H-2D; H2-D; H2-K1; K-f; H-2K; H2-K; H2-D1; H-2K(d); IAb; Ia2; Ia-2; Abeta; H-2Ab; H2-Ab; Rmcs1; I-Abeta
Classification
Immunodeficient Mouse Models
Phenotype
Chromosome
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Note: When using this mouse strain in a publication, please cite “NKG-MHC dKO (H2-K1/H2-Ab1/H2-D1) mice (Catalog C001705) were purchased from Cyagen.”
Strain Description
NKG-MHC dKO (H2-K1/H2-Ab1/H2-D1) mice, generated through targeted deletion of key MHC class I (H2-K1, H2-D1) and class II (H2-Ab1) molecules, effectively circumvent the immunological mismatch that triggers graft-versus-host disease (GvHD). This strategic ablation substantially delays GvHD onset and supports extended in vivo observation of human immune system reconstitution following PBMC engraftment. The model provides a high-resolution platform for longitudinal interrogation of human immune cell functionality and cross-species immune dynamics within a mouse host.
Application Area
Establishment of humanized immune system mouse model
Research on graft-versus-host disease (GvHD)
Research on the immune system, hematopoietic system, and blood disease
Cell line-derived xenograft (CDX) and drug screening and efficacy evaluation
Patient-derived xenograft (PDX) and drug screening and efficacy evaluation
Validation Data