B6-hCFB
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Strain Description
The B6-hCFB mouse is a humanized model constructed by replacing the sequence of the mouse Cfb gene in situ with the corresponding sequence from the human CFB gene. The homozygous B6-hCFB mice are viable and fertile and can be used for studies on age-related macular degeneration (AMD), atypical hemolytic uremic syndrome (aHUS), and systemic lupus erythematosus (SLE), and pathogenesis of immune-related diseases, as well as for CFB-targeted drug development.
Application Area
CFB-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of age-related macular degeneration (AMD)
Research on the pathological mechanisms and therapeutic approaches of atypical hemolytic uremic syndrome (aHUS)
Research on the pathological mechanisms and therapeutic approaches of systemic lupus erythematosus (SLE) and other immune-related diseases
Detailed Information