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B6-hCFB
Product ID:
C001710
Background:
C57BL/6JCya
Documents:
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Strain Description
The B6-hCFB mouse is a humanized model constructed by replacing the sequence of the mouse Cfb gene in situ with the corresponding sequence from the human CFB gene. The homozygous B6-hCFB mice are viable and fertile and can be used for studies on age-related macular degeneration (AMD), atypical hemolytic uremic syndrome (aHUS), and systemic lupus erythematosus (SLE), and pathogenesis of immune-related diseases, as well as for CFB-targeted drug development.
Application Area
Area
CFB-targeted drug screening, development, and evaluation
Area
Research on the pathological mechanisms and therapeutic approaches of age-related macular degeneration (AMD)
Area
Research on the pathological mechanisms and therapeutic approaches of atypical hemolytic uremic syndrome (aHUS)
Area
Research on the pathological mechanisms and therapeutic approaches of systemic lupus erythematosus (SLE) and other immune-related diseases
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