B6-hCFB
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-hCFB
Product ID
C001710
Gene Name
Background
C57BL/6JCya
Gene Alias
BF; FB; BFD; GBG; CFAB; CFBD; PBF2; AHUS4; FBI12; H2-Bf; ARMD14
Classification
Immune Target Humanized Models,Cytokine Humanized Models,Full-Gene Humanized Models,Ophthalmic Disease Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
6
Document
Note: When using this mouse strain in a publication, please cite “B6-hCFB mice (Catalog C001710) were purchased from Cyagen.”
Strain Description
The B6-hCFB mouse is a humanized model constructed by replacing the sequence of the mouse Cfb gene in situ with the corresponding sequence from the human CFB gene. The homozygous B6-hCFB mice are viable and fertile and can be used for studies on age-related macular degeneration (AMD), atypical hemolytic uremic syndrome (aHUS), and systemic lupus erythematosus (SLE), and pathogenesis of immune-related diseases, as well as for CFB-targeted drug development.
Application Area
CFB-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of age-related macular degeneration (AMD)
Research on the pathological mechanisms and therapeutic approaches of atypical hemolytic uremic syndrome (aHUS)
Research on the pathological mechanisms and therapeutic approaches of systemic lupus erythematosus (SLE) and other immune-related diseases
Validation Data