B6-hIL2RA
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
B6-hIL2RA
Product ID
C001713
Gene Name
Background
C57BL/6NCya
Gene Alias
p55; CD25; IL2R; IMD41; TCGFR; IDDM10
Classification
Tumor Target Humanized Models,Cytokine Humanized Models
NCBI ID
Phenotype
Chromosome
10
Document
Note: When using this mouse strain in a publication, please cite “B6-hIL2RA mice (Catalog C001713) were purchased from Cyagen.”
Strain Description
The B6-hIL2RA mouse is a humanized model constructed by replacing the sequence of the mouse Il2ra endogenous extracellular domain (aa.22~236) in situ with the corresponding extracellular domain (aa.22~240) from the human IL2RA. The murine signal peptide and transmembrane-cytoplasmic region (aa.1~21, aa.237~268) were preserved. The B6-hIL2RA mice can be used for the study of the pathogenesis of autoimmune diseases such as multiple sclerosis, type 1 diabetes, and rheumatoid arthritis, and certain malignancies, as well as for IL2RA-targeted drug development.
Application Area
IL2RA-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of autoimmune diseases such as multiple sclerosis, type 1 diabetes, and rheumatoid arthritis
Tumor immunology and other anti-tumor research
Validation Data