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B6-hIL2RA
Product ID:
C001713
Background:
C57BL/6NCya
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Strain Description
The B6-hIL2RA mouse is a humanized model constructed by replacing the sequence of the mouse Il2ra endogenous extracellular domain (aa.22~236) in situ with the corresponding extracellular domain (aa.22~240) from the human IL2RA. The murine signal peptide and transmembrane-cytoplasmic region (aa.1~21, aa.237~268) were preserved. The B6-hIL2RA mice can be used for the study of the pathogenesis of autoimmune diseases such as multiple sclerosis, type 1 diabetes, and rheumatoid arthritis, and certain malignancies, as well as for IL2RA-targeted drug development.
Application Area
Area
IL2RA-targeted drug screening, development, and evaluation
Area
Research on the pathological mechanisms and therapeutic approaches of autoimmune diseases such as multiple sclerosis, type 1 diabetes, and rheumatoid arthritis
Area
Tumor immunology and other anti-tumor research
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