B6-hB7-H3 (hCD276)
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
B6-hB7-H3 (hCD276)
Product ID
C001716
Gene Name
Background
C57BL/6NCya
Gene Alias
B7H3; B7-H3; B7RP-2; 4Ig-B7-H3
Classification
Tumor Target Humanized Models,Immune Target Humanized Models
NCBI ID
Phenotype
Chromosome
15
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Note: When using this mouse strain in a publication, please cite “B6-hB7-H3 (hCD276) mice (Catalog C001716) were purchased from Cyagen.”
Strain Description
The B6-hB7-H3 (hCD276) mouse is a humanized model constructed by replacing the sequence of the mouse Cd276 endogenous extracellular domain (aa.29~248) in situ with the corresponding extracellular domain from the human CD276. The murine signal peptide (aa.1~28) and aa.249~316 were preserved. The B6-hB7-H3 (hCD276) mice can be used for the study of the pathogenesis of various cancers such as breast cancer, glioblastoma, and non-small cell lung cancer, as well as for CD276-targeted drug development.
Application Area
CD276-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of various solid tumors (such as breast cancer, glioblastoma, and non-small cell lung cancer) and other cancers
Research on cancer immunotherapy
Validation Data