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B6-hCD40LG
Product ID:
C001720
Background:
C57BL/6NCya
Documents:
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Strain Description
The B6-hCD40LG mice are a humanized model constructed by using gene editing technology to replace the endogenous extracellular domain of the mouse Cd40lg gene with the extracellular domain of the human CD40LG gene. This model can be used for research on the disease mechanisms and treatment methods of autoimmune diseases, cardiovascular diseases, cancers, etc., as well as for CD40LG-targeted drug development.
Application Area
Area
Screening, development, and preclinical efficacy evaluation of CD40LG-targeted drugs
Area
Research on the pathological mechanisms and treatment methods of autoimmune diseases such as systemic lupus erythematosus (SLE) and lupus nephritis (LN)
Area
Research on cardiovascular diseases, cancers, etc.
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