B6-hCD40LG
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Age
Genotype
Sex
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Basic Information
Model Name
B6-hCD40LG
Product ID
C001720
Gene Name
Background
C57BL/6NCya
Gene Alias
IGM; IMD3; TRAP; gp39; CD154; CD40L; HIGM1; T-BAM; TNFSF5; hCD40L
Classification
Immune Target Humanized Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
X
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Note: When using this mouse strain in a publication, please cite “B6-hCD40LG mice (Catalog C001720) were purchased from Cyagen.”
Strain Description
The B6-hCD40LG mice are a humanized model constructed by using gene editing technology to replace the endogenous extracellular domain of the mouse Cd40lg gene with the extracellular domain of the human CD40LG gene. This model can be used for research on the disease mechanisms and treatment methods of autoimmune diseases, cardiovascular diseases, cancers, etc., as well as for CD40LG-targeted drug development.
Application Area
Screening, development, and preclinical efficacy evaluation of CD40LG-targeted drugs
Research on the pathological mechanisms and treatment methods of autoimmune diseases such as systemic lupus erythematosus (SLE) and lupus nephritis (LN)
Research on cardiovascular diseases, cancers, etc.
Validation Data