B6-hGCGR
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-hGCGR
Product ID
C001723
Gene Name
Background
C57BL/6NCya
Gene Alias
GGR; GL-R; MVAH
Classification
Metabolic Target Humanized Models,Full-Gene Humanized Models,Metabolic Disease Models
NCBI ID
Phenotype
Chromosome
17
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Note: When using this mouse strain in a publication, please cite “B6-hGCGR mice (Catalog C001723) were purchased from Cyagen.”
Strain Description
The B6-hGCGR mouse is a humanized model constructed by replacing the sequence of the mouse Gcgr gene in situ with the corresponding sequence from the human GCGR gene. The B6-hGCGR mice can be used for studies on obesity, type 2 diabetes, metabolic dysfunction-associated steatohepatitis, and other glucose-related metabolic disorders, as well as for GCGR-targeted drug development.
Application Area
GCGR-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of obesity, type 2 diabetes, and Metabolic Dysfunction - Associated Steatohepatitis (MASH)
Research on other glucose-related metabolic disorders
Validation Data