BALB/c-hCRBN
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Strain Description
BALB/c-hCRBN mice are humanized models generated by gene editing technology, in which the exon 2 to partial intron 2 of the mouse Crbn gene was replaced in situ with the Exon 2~11 of the coding sequence (CDS) of human CRBN gene. This model can be used to study the pathological mechanisms and therapeutic methods of autosomal recessive nonsyndromic intellectual disability and multiple myeloma and other hematological cancers, as well as the screening, development, and preclinical efficacy and safety evaluation of CRBN-based targeted protein degradation (TBD) therapies.
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Screening, development, and preclinical efficacy evaluation of CRBN-based targeted protein degradation (TBD) therapies
Study of pathological mechanisms and therapeutic methods for autosomal recessive nonsyndromic intellectual disability
Study of pathological mechanisms and therapeutic methods for multiple myeloma and other hematological cancers
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