B6-hTNFRSF13B
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Model Name
B6-hTNFRSF13B
Product ID
C001725
Gene Name
Background
C57BL/6NCya
Gene Alias
CVID; RYZN; TACI; CD267; CVID2; IGAD2; TNFRSF14B
Classification
Immune Target Humanized Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
17
Document
Note: When using this mouse strain in a publication, please cite “B6-hTNFRSF13B mice (Catalog C001725) were purchased from Cyagen.”
Strain Description
The B6-hTNFRSF13B mouse is a humanized model constructed by replacing the exon 2 plus partial intron 2 of the mouse Tnfrsf13b gene in situ with the "Kozak-TNFRSF13B chimeric CDS-3'UTR of mouse Tnfrsf13b-WPRE-BGH pA" cassette. The B6-hTNFRSF13B mice can be used for studies on common variable immunodeficiency (CVID), and pathogenesis of immune-related diseases, as well as for TNFRSF13B-targeted drug development.
Application Area
TNFRSF13B-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of common variable immunodeficiency (CVID)
Validation Data