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B6-hTNFRSF13B
Product ID:
C001725
Background:
C57BL/6NCya
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Strain Description
The B6-hTNFRSF13B mouse is a humanized model constructed by replacing the exon 2 plus partial intron 2 of the mouse Tnfrsf13b gene in situ with the "Kozak-TNFRSF13B chimeric CDS-3'UTR of mouse Tnfrsf13b-WPRE-BGH pA" cassette. The B6-hTNFRSF13B mice can be used for studies on common variable immunodeficiency (CVID), and pathogenesis of immune-related diseases, as well as for TNFRSF13B-targeted drug development.
Application Area
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TNFRSF13B-targeted drug screening, development, and evaluation
Area
Research on the pathological mechanisms and therapeutic approaches of common variable immunodeficiency (CVID)
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