The CD68 gene encodes a transmembrane glycoprotein primarily expressed on the surface of macrophages and other mononuclear phagocytes, with high expression levels in monocytes and tissue macrophages. The Cd68-P2A-CreERT2 mouse model was constructed using gene editing technology to integrate the tamoxifen-inducible CreERT2 recombinase expression element into the endogenous mouse Cd68 gene. Without tamoxifen treatment, the CreERT2 recombinase remains in the cytoplasm; only upon tamoxifen induction can it translocate to the nucleus and initiate recombination. When Cd68-P2A-CreERT2 mice are crossed with mice containing loxP sites, tamoxifen induction is expected to trigger Cre-mediated recombination between loxP sites in monocytes and macrophages of the offspring.