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B6-hFOLH1 (hPSMA)
Product ID:
C001779
Background:
C57BL/6NCya
Documents:
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Strain Description
The B6-hFOLH1 mouse is a humanized model constructed by replacing aa.45 to partial intron 2 of the mouse Folh1 gene with the human FOLH1 cDNA of the extracellular domain (aa.44~750)-3'UTR of mouse Folh1-WPRE-BGH pA cassette. The murine cytoplasmic-transmembrane domain (aa.1~44) will be preserved. B6-hFOLH1 mice can be used for research into the pathogenesis of hyperhomocysteinemia and various solid tumors like prostate cancer, as well as for the screening, development, and safety evaluation of FOLH1-targeted drugs.
Application Area
Area
FOLH1-targeted drug screening, development, and evaluation
Area
Research on the pathological mechanisms and therapeutic approaches of hyperhomocysteinemia
Area
Research on the pathological mechanisms and therapeutic approaches of various solid tumors like prostate cancer
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