B6-hFOLH1 (hPSMA)
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
B6-hFOLH1 (hPSMA)
Product ID
C001779
Gene Name
Background
C57BL/6NCya
Gene Alias
PSM; FGCP; FOLH; GCP2; PSMA; mGCP; GCPII; NAALAD1
Classification
Tumor Target Humanized Models,Full-Gene Humanized Models
NCBI ID
Phenotype
Chromosome
11
Document
Note: When using this mouse strain in a publication, please cite “B6-hFOLH1 (hPSMA) mice (Catalog C001779) were purchased from Cyagen.”
Strain Description
The B6-hFOLH1 mouse is a humanized model constructed by replacing aa.45 to partial intron 2 of the mouse Folh1 gene with the human FOLH1 cDNA of the extracellular domain (aa.44~750)-3'UTR of mouse Folh1-WPRE-BGH pA cassette. The murine cytoplasmic-transmembrane domain (aa.1~44) will be preserved. B6-hFOLH1 mice can be used for research into the pathogenesis of hyperhomocysteinemia and various solid tumors like prostate cancer, as well as for the screening, development, and safety evaluation of FOLH1-targeted drugs.
Application Area
FOLH1-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of hyperhomocysteinemia
Research on the pathological mechanisms and therapeutic approaches of various solid tumors like prostate cancer
Validation Data