B6-hIL6ST
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Strain Description
The B6-hIL6ST mouse is a humanized model constructed by replacing the endogenous partial extracellular domain (c.67~1834) of the mouse Il6st gene with the human IL6ST partial extracellular domain (c.67~1840). The murine signal peptide, transmembrane, and cytoplasmic domains are preserved. B6-hIL6ST mice can be used for research into the pathogenesis of inflammatory and autoimmune diseases, as well as certain tumors, and for the screening, development, and safety evaluation of IL6ST-targeted drugs.
Application Area
IL6ST-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of inflammatory and autoimmune diseases
Research on the pathological mechanisms and therapeutic approaches of certain tumors
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