B6-hIL6ST
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Genotype
Sex
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Basic Information
Model Name
B6-hIL6ST
Product ID
C001786
Gene Name
Background
C57BL/6NCya
Gene Alias
CD130; GP130; HIES4; IMD94; STWS2; CDW130; HIES4A; HIES4B; IL-6RB; sGP130
Classification
Cytokine Humanized Models
NCBI ID
Phenotype
Chromosome
5
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Note: When using this mouse strain in a publication, please cite “B6-hIL6ST mice (Catalog C001786) were purchased from Cyagen.”
Strain Description
The B6-hIL6ST mouse is a humanized model constructed by replacing the endogenous partial extracellular domain (c.67~1834) of the mouse Il6st gene with the human IL6ST partial extracellular domain (c.67~1840). The murine signal peptide, transmembrane, and cytoplasmic domains are preserved. B6-hIL6ST mice can be used for research into the pathogenesis of inflammatory and autoimmune diseases, as well as certain tumors, and for the screening, development, and safety evaluation of IL6ST-targeted drugs.
Application Area
IL6ST-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of inflammatory and autoimmune diseases
Research on the pathological mechanisms and therapeutic approaches of certain tumors
Validation Data