B6-hLAG3
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Strain Description
The B6-hLAG3 mouse is a humanized model constructed by replacing the endogenous extracellular domain (aa.24~442) of the mouse Lag3 gene with the human LAG3 extracellular domain (aa.23~450). The murine signal peptide (aa.1~23) and aa.443~521 are preserved. B6-hLAG3 mice can be used for research into the pathogenesis of various diseases, including malignant tumors, chronic infections, and autoimmune diseases, as well as for the screening, development, and safety evaluation of LAG3-targeted drugs.
Application Area
LAG3-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of malignant tumors such as melanoma, colorectal cancer, and non-small cell lung carcinoma
Research on the pathological mechanisms and therapeutic approaches of chronic infections including HIV infection, hepatitis B, and tuberculosis
Research on the pathological mechanisms and therapeutic approaches of autoimmune diseases like rheumatoid arthritis and Hashimoto's thyroiditis
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