B6-huASGR1
Product Type
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Genotype
Sex
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Basic Information
Model Name
B6-huASGR1
Product ID
C001788
Gene Name
Background
C57BL/6JCya
Gene Alias
HL-1; ASGPR; ASGPR1; CLEC4H1
Classification
Metabolic Target Humanized Models,Full-Gene Humanized Models,Metabolic Disease Models
NCBI ID
Phenotype
Chromosome
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Note: When using this mouse strain in a publication, please cite “B6-huASGR1 mice (Catalog C001788) were purchased from Cyagen.”
Strain Description
The B6-huASGR1 mouse model was generated by replacing sequences from the ATG start codon to the TAG stop codon of the endogenous mouse Asgr1 gene with the sequences from the ATG start codon to the TAA stop codon of the human ASGR1 gene. This model can be used to study the pathological mechanisms and therapeutic approaches for cardiovascular and liver diseases, as well as for the development of ASGR1-targeted drugs.
Application Area
ASGR1-targeted drug screening, development, and evaluation
Research on pathological mechanisms and therapeutic approaches for cardiovascular and liver diseases
Validation Data