B6-hTREM1
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Sex
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Basic Information
Model Name
B6-hTREM1
Product ID
C001790
Gene Name
Background
C57BL/6NCya
Gene Alias
CD354; TREM-1
Classification
Full-Gene Humanized Models
NCBI ID
Phenotype
Chromosome
6
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Note: When using this mouse strain in a publication, please cite “B6-hTREM1 mice (Catalog C001790) were purchased from Cyagen.”
Strain Description
The B6-hTREM1 mouse is a humanized model, constructed by replacing the mouse Trem1 signal peptide (aa. 1-20) and endogenous extracellular domain (aa. 21-202) with the human TREM1 signal peptide (aa. 1-20) and extracellular domain (aa. 21-205), while preserving the murine aa. 203-230. B6-hTREM1 mice can be used for research into the pathogenesis of various inflammatory diseases, cancers, neurodegenerative diseases, and kidney-related diseases, as well as for the screening, development, and safety evaluation of TREM1-targeted drugs.
Application Area
TREM1-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of inflammatory diseases such as inflammatory bowel disease (IBD) and rheumatoid arthritis (RA)
Research on the pathological mechanisms and therapeutic approaches of cancers such as glioma and hepatocellular carcinoma
Research on the pathological mechanisms and therapeutic approaches of neurodegenerative diseases such as Parkinson's disease (PD) and Alzheimer's disease (AD)
Validation Data