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B6-hTREM1
Product ID:
C001790
Background:
C57BL/6NCya
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Strain Description
The B6-hTREM1 mouse is a humanized model, constructed by replacing the mouse Trem1 signal peptide (aa. 1-20) and endogenous extracellular domain (aa. 21-202) with the human TREM1 signal peptide (aa. 1-20) and extracellular domain (aa. 21-205), while preserving the murine aa. 203-230. B6-hTREM1 mice can be used for research into the pathogenesis of various inflammatory diseases, cancers, neurodegenerative diseases, and kidney-related diseases, as well as for the screening, development, and safety evaluation of TREM1-targeted drugs.
Application Area
Area
TREM1-targeted drug screening, development, and evaluation
Area
Research on the pathological mechanisms and therapeutic approaches of inflammatory diseases such as inflammatory bowel disease (IBD) and rheumatoid arthritis (RA)
Area
Research on the pathological mechanisms and therapeutic approaches of cancers such as glioma and hepatocellular carcinoma
Area
Research on the pathological mechanisms and therapeutic approaches of neurodegenerative diseases such as Parkinson's disease (PD) and Alzheimer's disease (AD)
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