B6-hIL1B Mouse
Product Name
B6-hIL1B Mouse
Product ID
C001791
Strain Name
C57BL/6NCya-Il1btm1(hIL1B)/Cya
Backgroud
C57BL/6NCya
When using this mouse strain in a publication, please cite “B6-hIL1B Mouse (Catalog C001791) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Gene Name
Gene Alias
IL-1, IL1F2, IL1beta, IL1-BETA
NCBI ID
Chromosome
Chr 2
MGI ID
Datasheet
Strain Description
The IL1B gene encodes for Interleukin-1 beta (IL-1β), a potent pro-inflammatory cytokine that is a critical mediator of the inflammatory response and innate immunity. Gene expression of IL1B is primarily observed in activated macrophages and monocytes, but also in other immune cells like dendritic cells and even some epithelial cells and keratinocytes [1]. IL-1β is initially synthesized as an inactive precursor protein (pro-IL-1β), which then undergoes proteolytic processing by caspase-1 (CASP1/ICE) within inflammasome complexes to yield its mature, biologically active form. This mature protein plays diverse roles in cellular activities, including cell proliferation, differentiation, apoptosis, and fever generation. It is involved in inducing the production of other inflammatory mediators and activating various immune cells [2]. Aberrant or increased IL-1β expression and activity are associated with a wide range of inflammatory and autoinflammatory diseases, such as Cryopyrin-Associated Periodic Syndromes (CAPS), gout, rheumatoid arthritis (RA), recurrent pericarditis, and type 2 diabetes (T2D). It has also been implicated in various cancers and neurodegenerative conditions [3-4].
The B6-hIL1B mouse is a humanized model, constructed by replacing the coding sequences of the endogenous mouse Il1b gene with the coding sequences of the human IL1B gene. B6-hIL1B mice can be used for research into the pathogenesis of various inflammatory diseases, autoimmune diseases, cancers, and neurodegenerative diseases, as well as for the screening, development, and safety evaluation of IL1B-targeted drugs.
Reference
Lopez-Castejon G, Brough D. Understanding the mechanism of IL-1β secretion. Cytokine Growth Factor Rev. 2011 Aug;22(4):189-95.
Dinarello CA. Overview of the IL-1 family in innate inflammation and acquired immunity. Immunol Rev. 2018 Jan;281(1):8-27.
Baker KJ, Houston A, Brint E. IL-1 Family Members in Cancer; Two Sides to Every Story. Front Immunol. 2019 Jun 7;10:1197.
Tylutka A, Walas Ł, Zembron-Lacny A. Level of IL-6, TNF, and IL-1β and age-related diseases: a systematic review and meta-analysis. Front Immunol. 2024 Mar 1;15:1330386.
Strain Strategy
The sequences from the ATG start codon to the TAA stop codon of the endogenous mouse Il1b gene will be replaced with the sequences from the ATG start codon to the TAA stop codon of the human IL1B gene. The function of the mouse Il1bos gene will be affected.
Figure 1. Gene editing strategy of B6-hIL1B mice.
Application Area
IL1B-targeted drug screening, development, and evaluation;
Research on the pathological mechanisms and therapeutic approaches of gout, rheumatoid arthritis (RA), recurrent pericarditis, type 2 diabetes (T2D), and other inflammatory and autoimmune diseases;
Research on the pathological mechanisms and therapeutic approaches of cancers;
Research on the pathological mechanisms and therapeutic approaches of neurodegenerative diseases.
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