B6-hNRL
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
B6-hNRL
Product ID
C001799
Gene Name
Background
C57BL/6JCya
Gene Alias
RP27; D14S46E; NRL-MAF
Classification
Full-Gene Humanized Models,Ophthalmic Disease Models
NCBI ID
Phenotype
Chromosome
14
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Note: When using this mouse strain in a publication, please cite “B6-hNRL mice (Catalog C001799) were purchased from Cyagen.”
Strain Description
The B6-hNRL mouse is a humanized model, constructed by replacing the sequences from 5'UTR to 3'UTR of the endogenous mouse Nrl gene with the corresponding human NRL gene sequence. B6-hNRL mice can be used for research into the pathogenesis of various inherited retinal degenerative diseases such as Retinitis Pigmentosa (RP). They are also useful for the screening, development, and safety evaluation of NRL-targeted drugs.
Application Area
NRL-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of various inherited retinal degenerative diseases such as Retinitis Pigmentosa (RP)
Validation Data