B6-hIL2RG
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
B6-hIL2RG
Product ID
C001801
Gene Name
Background
C57BL/6NCya
Gene Alias
P64; CIDX; IMD4; CD132; SCIDX; IL-2RG; SCIDX1
Classification
Immune Target Humanized Models,Full-Gene Humanized Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
X
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Note: When using this mouse strain in a publication, please cite “B6-hIL2RG mice (Catalog C001801) were purchased from Cyagen.”
Strain Description
The B6-hIL2RG mouse is a humanized model, constructed by replacing the coding sequences of the endogenous mouse Il2rg gene with the coding sequences of the human IL2RG gene. B6-hIL2RG mice can be used for research into the pathogenesis of X-linked severe combined immunodeficiency (X-SCID), certain autoimmune diseases, and hematological malignancies, as well as for the screening, development, and safety evaluation of IL2RG-targeted drugs.
Application Area
IL2RG-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of X-linked severe combined immunodeficiency (X-SCID)
Research on the pathological mechanisms and therapeutic approaches of certain autoimmune diseases
Research on the pathological mechanisms and therapeutic approaches of hematological malignancies
Validation Data