B6-h4-1BB-L (hTNFSF9)
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
B6-h4-1BB-L (hTNFSF9)
Product ID
C001807
Gene Name
Background
C57BL/6NCya
Gene Alias
CD137L; TNLG5A; 4-1BB-L
Classification
Tumor Target Humanized Models,Immune Target Humanized Models,Full-Gene Humanized Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
19
Document
Note: When using this mouse strain in a publication, please cite “B6-h4-1BB-L (hTNFSF9) mice (Catalog C001807) were purchased from Cyagen.”
Strain Description
The B6-h4-1BB-L (hTNFSF9) mouse is a humanized model constructed by in situ replacement of the coding sequence of the murine endogenous Tnfsf9 gene with that of the human TNFSF9 gene. This model can be used in studies of cancer immunotherapy and autoimmune diseases, as well as in the screening, development, and safety evaluation of 4-1BB-L-targeted drugs.
Application Area
Screening, development, and preclinical evaluation of TNFSF9-targeted drugs
Research on cancer immunology
Research on the pathological mechanisms and treatment methods of autoimmune diseases
Validation Data