B6-hCCL1
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-hCCL1
Product ID
C001814
Gene Name
Background
C57BL/6NCya
Gene Alias
P500; SISe; TCA3; I-309; SCYA1
Classification
Cytokine Humanized Models,Full-Gene Humanized Models
NCBI ID
Phenotype
Chromosome
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Note: When using this mouse strain in a publication, please cite “B6-hCCL1 mice (Catalog C001814) were purchased from Cyagen.”
Strain Description
The B6-hCCL1 mouse is a humanized model, constructed by replacing the coding sequences of the endogenous mouse Ccl1 gene with the coding sequences of the human CCL1 gene. B6-hCCL1 mice can be used for research into the pathogenesis of various inflammatory and immune-related disorders, including asthma, atopic dermatitis, rheumatoid arthritis (RA), chronic obstructive pulmonary disease (COPD), tuberculosis, and certain cancers like breast cancer, cervical cancer, and Kaposi Sarcoma, as well as for the screening, development, and safety evaluation of CCL1-targeted drugs.
Application Area
CCL1-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of various inflammatory and immune-related disorders, including asthma, atopic dermatitis (AD), rheumatoid arthritis (RA), chronic obstructive pulmonary disease (COPD), tuberculosis
Research on certain cancers like breast cancer, cervical cancer, and Kaposi Sarcoma
Validation Data